We present JWST observations of star-forming populations in nearby, metal-poor systems. These JWST NIRCam, MIRI and NIRSpec observing programs were designed to characterize the star-formation mechanisms of early Universe like systems, in accessible conditions analogous to cosmic noon (z ~ 1.5-2), when such activity peaked. Our programs observed four local star-forming systems over a range of metal enrichment levels, including N79 in the LMC (Z ≈ 0.5 Z⊙), NGC 346 in the SMC (Z ≈ 0.3 Z⊙), NGC 6822 (Z ≈ 0.2 Z⊙), and I Zw 18 (Z ≈ 0.03 Z⊙), at a variety of wavelengths, providing spatially-resolved photometry of IR-bright sources at photometric depths over 10 magnitudes below Spitzer and 2 magnitudes below HST at comparable wavelengths. JWST spectroscopy has followed up on these deep photometric stellar population studies of star-forming galaxies. Here I will give and overview of the key photometric and spectroscopic results.