Loaders, integral tools in the malware ecosystem, have evolved from niche utilities to widely accessible commodities in underground markets, enabling threat actors to deploy payloads with ease. While cybersecurity efforts focus heavily on analyzing payloads, loaders, the mechanisms behind obfuscation and delivery, remain underexplored. This talk goes into the continuous battle between loaders innovations and cybersecurity defenses, highlighting techniques like in-memory execution and anti-analysis mechanisms that challenge detection solutions. Attendees will gain insights into the latest loader advancements, their impact on modern cyberattacks, and strategies for mitigating their threats, offering valuable perspectives for researchers and security professionals alike.