Twitter is among the most widely used platforms for staying updated on current events and for following prominent figures such as celebrities, influencers, and political leaders. Politicians utilize Twitter to share their viewpoints and disseminate information about legislative changes, prompting inquiries into their role in influencing public opinion on social media. This study began by extracting a large sample of Tweets (n = 5,875,315) authored by current U.S. Governors, Senators, and Representatives (as of March 2022) which were then filtered to examine a set of cannabis-related tweets (n = 10,086) to understand the nature of political discourse on social media. The entire subsample of cannabis-related tweets is analyzed with descriptive and inferential statistics, while a subsample (n = 1,714) is subject to a qualitative thematic analysis. The majority of tweets are informative in nature and maintain a neutral tone, although some politicians—mostly authored by Democratic politicians—use non-neutral language to convey their message about the War on Drugs and ongoing cannabis prohibition. Cannabis tweets can be categorized into four categories: economy, government/governing process, public health, and justice. The results are discussed in the context of ongoing policy liberalization with an eye toward their implications for future research and our understanding of political discourse on social media.