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UID:pretalx-juliacon-2026-QACULP@pretalx.com
DTSTART;TZID=CET:20260813T110000
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DESCRIPTION:Protein-DNA binding can depend on sequence changes even outside
  direct complex contact regions. While an MD-based protocol can capture th
 is indirect readout with high correlation to experiment\, its cost limits 
 large-scale use. We present a Julia package to estimate DNA deformation fr
 ee energies with practical analytical models optimized from simulation tra
 jectories. These models aim to explain these affinity differences at much 
 lower cost\, enabling broader screening or sequence optimization.
DTSTAMP:20260502T093501Z
LOCATION:Room 4
SUMMARY:Modeling Indirect Readout through DNA Deformation Free Energies in 
 Julia - Christian Sustay Martinez
URL:https://pretalx.com/juliacon-2026/talk/QACULP/
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