Large-Scale Mechanistic Modeling of Immune Pathway in Julia
In this poster, a large-scale mathematical model of the JAK-STAT pathway was implemented in Julia to explore IFN-I ligand discrimination. Model fitting, often time-consuming in large-scale models, was performed to different temporal IFN-I inputs. Julia’s efficiency significantly accelerated this process by expediting sensitivity analysis, parameter estimation and identifiability analysis. The resulting model facilitates investigation into the mechanisms underlying ligand discrimination.